Product?Name:Neohesperidin?dihydrochalcone

Botanical?Name:Citrus?aurantium

Part?Used:?Fruit

Application:?Natural?Sweetener

Brief?Info:1-99%

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Active?Ingredient:Neohesperidin?dihydrochalcone

CAS?No.:20702-77-6

M.Formula：?C28H36O15??　　

M.Weight：612.58　　

Structural?formula:

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Specification

(1)1-99%?Neohesperidosyl?dihydrochalcone

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Description

Neohesperidin?dihydrochalcone,?sometimes?abbreviated?to?neohesperidin?

DC?or?simply?NHDC,?is?an?artificial?sweetener?derived?from?citrus.

NHDC?was?discovered?during?the?1960s?as?part?of?a?United?States?Department?

of?Agriculture?research?program?to?find?methods?for?minimizing?the?taste?of?bitter?

flavorants?in?citrus?juices.?Neohesperidin?is?one?such?bitter?compound.?When?

treated?with?potassium?hydroxide?or?another?strong?base,?and?then?catalytically?

hydrogenated,?it?becomes?NHDC,?a?compound?roughly?15001800?times?

sweeterthan?sugar?at?threshold?concentrations;?around?340?times?sweeter?than?

sugar?weightfor?weight.?Its?potency?is?naturally?affected?by?such?factors?as?the?

application?in?which?it?is?used,?and?the?pH?of?the?product.Like?other?highly?sweet?

glycosides,?such?as?glycyrrhizin?and?those?found?in?stevia,?NHDC's?sweet?taste?

has?a?slower?onset?than?sugar's?and?lingers?in?the?mouth?for?some?time.?

Unlike?aspartame,?NHDC?is?stable?to?elevated?temperatures?and?to?acidic?or?basic?

conditions,?and?so?can?be?used?in?applications?that?require?a?long?shelf?life.?

NHDC?itself?can?stay?foodsafe?for?up?to?five?years?when?stored?in?optimal?conditions.

The?European?Union?approved?NHDC's?use?as?a?sweetener?in?1994.?It?has?

not?been?approved?as?a?sweetener?in?the?United?States.?It?is?sometimes?said?

that?NHDC?is?considered?a?Generally?Recognized?as?Safe?flavour?enhancer?

by?the?Flavour?and?Extract?Manufacturers'?Association,?which?is?a?trade?group?

with?no?legal?standing.?NHDC?has?never?appeared?on?the?FDA's?GRAS?listing.

It?is?particularly?effective?in?masking?the?bitter?tastes?of?other?compounds?found?

in?citrus,?including?limonin?and?naringin.?Industrially,?it?is?produced?by?extracting?

neohesperidin?from?the?bitter?orange,?and?then?hydrogenating?this?to?make?NHDC.

The?product?is?well?known?for?having?a?strong?synergistic?effect?when?used?in?

conjunction?with?other?artificial?sweeteners?such?as?aspartame,?saccharin,?

acesulfame?potassium,?and?cyclamate,?as?well?as?sugar?alcohols?such?as?

xylitol.?NHDC?usage?boosts?the?effects?of?these?sweeteners?at?lower?concentrations

?than?would?otherwise?be?required;?smaller?amounts?of?other?sweeteners?are?needed.?

This?provides?a?cost?benefit.

As?a?flavour?enhancer,?NHDC?is?used?in?a?wide?range?of?products?and?is?indicated?

by?the?E?number?E?959.?It?is?noted?particularly?for?enhancing?sensory?effects?(known

?in?the?industry?as?'mouth?feel').?An?example?of?this?is?'creaminess'?in?dairy?foods?

such?as?yogurt?and?ice?cream,?but?is?also?widely?favoured?for?use?in?otherwise?

naturally?bitter?products.?Pharmaceutical?companies?are?fond?of?the?product?as?a?

means?of?reducing?the?bitterness?of?pharmacological?drugs?in?tablet?form,?and?it?

has?been?used?for?livestock?feed?as?a?means?of?reducing?feeding?time.?Other?

products?NHDC?can?be?found?in?may?include?a?wide?variety?of?alcoholic?beverages?

(and?nonalcoholic),?savoury?foods,?toothpaste,?mouthwash?and?condiments?such?

as?ketchup?and?mayonnaise.

NHDC?in?pure?form?is?found?as?a?white?substance?not?unlike?powdered?sugar.

?In?food?it?is?used?as?a?flavour?enhancer?in?concentrations?of?around?45?parts?

per?million?(ppm)?and?as?an?artificial?sweetener?at?around?15-20?ppm.

Research?has?shown?that?at?strengths?of?around?and?above?20?ppm,?

NHDC?can?produce?side?effects?such?as?nausea?and?migraine.?

This?is?not?widely?documented,?however?is?unquestionably?known?within?the?

food?science?communities?that?have?worked?with?the?product,?and?many?recommend?

wearing?a?surgical?mask?when?handling?pure?NHDC.

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Certificate?of?Analysis