1-Propanethiol
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- Category :
Organic chemicals and Derivatives/Aroma compounds
- CAS NO : 107-03-9
- EC NO : 203-455-5
- Molecular Formula : C3H7NaS
- Main Specifications : 99% min
- Synonyms : n-Propyl mercaptan;propane-1-thiol;sodium propane-1-thiolate;Propyl mercaptan;
Package: 25kg，50kg 200kg
Uses : Mainly used as an intermediate in organic synthesis
Molecular Structure:
Product description:
What is the chemical of 1-Propanethiol?
Appearance: Colorless or pale yellow liquid with a strong, unpleasant foul odor, similar to cabbage, natural gas, or onions.;
Assay：99%min by GC ;
IR Identity: conform to standard ;
HNMR： conform to standard ;
carbon spectrum: conform to standard ;
Water by K. F.:0.5% max or as per the customer’s request ;
Loss on drying:0.5% max. or as per the customer’s request ;
Melting point: -113 °C;
boiling point: 67-68 ° C (at standard atmospheric pressure);
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Usage: Mainly used as an intermediate in organic synthesis, especially in the pesticide industry, for the synthesis of organophosphorus insecticides (such as propiconazole and methomyl), herbicides (such as glyphosate), and soil insecticides. In addition, it is also used in the synthesis of fragrances, pharmaceutical intermediates (such as LRRK2 inhibitors for Parkinson's disease research), and other fine chemicals.
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Synthesis route: In industry, it is mainly prepared through the following methods:
Reaction between bromopropane and thiourea: Reflux thiourea and bromopropane in methanol, then add sodium hydroxide solution for reaction, followed by acidification with sulfuric acid and distillation purification.
Halogenated propane reacts with sodium hydrosulfide: Halogenated propane (such as chloropropane or bromopropane) undergoes nucleophilic substitution reaction with sodium hydrosulfide (NaSH).
Catalytic reaction between propanol and hydrogen sulfide: At 300-380 ° C, propanol reacts with hydrogen sulfide (H ? S) through a catalyst (such as alumina) to produce propanethiol.
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